RESOURCES

PROTOCOLS

DATASETS

Human Inner Ear Organoid Development Atlas (IODA)

We are constructing an online portal, in collaboration with the gEAR database team, for accessing the time course scRNA-seq analysis from Steinhart et al.

Data derived from:

Steinhart MR, van der Valk WH, Osorio D, Serdy SA, Zhang J, Nist-Lund C, Sun L, Lee J†*, Koehler KR†*. Mapping oto-pharyngeal development in a human inner ear organoid model. Development 150, (2023).

Clicking the link above will redirect you to a UCSC Cell Browser-powered interface to explore scRNA-seq data from day-6 and day-29 human skin organoids generated from WA25 hESCs and DSP-GFP hiPSCs. We would like to thank Hongyu Gao at the Indiana University Center for Medical Genomics for helping to establish this web portal.

Data derived from:

Lee J, Rabbani C, Gao H, Steinhart M, Woodruff BW, Pflum Z, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature, 2020, June; doi: https://doi.org/10.1038/s41586-020-2352-3

Here we assembled a comprehensive multi-omics reference atlas of prenatal human skin (7–17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches of the skin. This atlas revealed that crosstalk between non-immune and immune cells underpins the formation of hair follicles, is implicated in scarless wound healing and is crucial for skin angiogenesis.

Data derived from:

Gopee NH, Huang N, Olabi B, Admane C, Botting RA, Foster AR, Torabi F, Winheim E, Sumanaweera D, Goh I, Miah M, Stephenson E, Tun WM, Moghimi P, Rumney B, He P, Lawrence S, Roberts K, Sidhpura K, Englebert J, Jardine L, Reynolds G, Rose A, Ganier C, Rowe V, Pritchard S, Mulas I, Fletcher J, Popescu DM, Poyner E, Dubois A, Filby A, Lisgo S, Barker RA, Park JE, Vento-Tormo R, Le PA, Serdy S, Kim J, Deakin C, Lee J, Nikolova M, Rajan N, Ballereau S, Li T, Moore J, Horsfall D, Lozada DB, O’Toole EA, Treutlein B, Bayraktar O, Kasper M, Mazin P, Gambardella L, Koehler KR†*, Teichmann SA†*, Haniffa M†*. A prenatal skin atlas reveals immune regulation of human skin morphogenesis. Nature 635, 679–689 (2024).